Administrators should occasionally delete old user profiles (retired or inactive users, etc.) from C:\Users on Windows workstations and servers. The Windows user profile cleanup task is most commonly performed on Remote Desktop Services (RDS) terminal servers.
The main problem with RDS servers is the constant growth in the size of the user profile directories on the hard disk. This problem is partially solved by user profile size quotas using FSRM or NTFS quotas, using roaming profiles such as FSLogix or User Profile Disk, redirected folders, etc. However, if you have a large number of RDS users, over time the C:\Users folder will contain a large number of directories with old (unused) user profiles.